The prokineticins: neuromodulators and mediators of inflammation and myeloid cell-dependent angiogenesis
L Negri, N Ferrara - Physiological reviews, 2018 - journals.physiology.org
The mammalian prokineticins family comprises two conserved proteins, EG-VEGF/PROK1
and Bv8/PROK2, and their two highly related G protein-coupled receptors, PKR1 and PKR2 …
and Bv8/PROK2, and their two highly related G protein-coupled receptors, PKR1 and PKR2 …
Prokineticin-receptor network: mechanisms of regulation
R Lattanzi, R Miele - Life, 2022 - mdpi.com
Prokineticins are a new class of chemokine-like peptides that bind their G protein-coupled
receptors, PKR1 and PKR2, and promote chemotaxis and the production of pro …
receptors, PKR1 and PKR2, and promote chemotaxis and the production of pro …
Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency
KH Cox, LMB Oliveira, L Plummer… - Human molecular …, 2018 - academic.oup.com
A major challenge in human genetics is the validation of pathogenicity of heterozygous
missense variants. This problem is well-illustrated by PROKR2 variants associated with …
missense variants. This problem is well-illustrated by PROKR2 variants associated with …
Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
V Murcia-Belmonte, M Tercero-Díaz, D Barrasa-Martín… - Cellular …, 2022 - Elsevier
The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic
hypogonadism and anosmia, is due to mutations in the ANOS1 gene that encodes for the …
hypogonadism and anosmia, is due to mutations in the ANOS1 gene that encodes for the …
Interaction of Prokineticin Receptors with Accessory Proteins
R Lattanzi, R Miele - Encyclopedia, 2023 - mdpi.com
Definition G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate
the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G …
the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G …
The role of snapin in regulation of brain homeostasis
J Li, X Huang, Y An, X Chen, Y Chen… - Neural Regeneration …, 2024 - journals.lww.com
Brain homeostasis refers to the normal working state of the brain in a certain period, which is
important for overall health and normal life activities. Currently, there is a lack of effective …
important for overall health and normal life activities. Currently, there is a lack of effective …
Physical and functional interaction of Snapin with Cav1. 3 calcium channel impacts channel protein trafficking in atrial myocytes
XL Sun, J Yuan, T Jin, XQ Cheng, Q Wang, J Guo… - Cellular …, 2017 - Elsevier
The L-type Ca 2+ channel (LTCC) Cav1. 3 plays a critical role in generating electrical activity
in atrial myocytes and cardiac pacemaker cells. However, the molecular and functional basis …
in atrial myocytes and cardiac pacemaker cells. However, the molecular and functional basis …
Snapin 蛋白在调节脑稳态中的作用
J Li, X Huang, Y An, X Chen, Y Chen, M Xu… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
脑稳态是指大脑在一定时间内的正常工作状态, 对于人体的健康和正常生命活动具有重要意义.
目前针对脑稳态失调所带来的不良后果, 尚缺乏有效的治疗方法. 近期, 许多研究人员报道snapin …
目前针对脑稳态失调所带来的不良后果, 尚缺乏有效的治疗方法. 近期, 许多研究人员报道snapin …
[HTML][HTML] Interactions between human hemoglobin subunits and peroxiredoxin 2
Q Ma, L An, H Tian, J Liu, L Zhang, X Li… - Frontiers in Bioscience …, 2019 - imrpress.com
Red blood cells (RBCs) are exposed to exogenous reactive oxygen species in the
circulatory system. To this end, the interactions between the different hemoglobin (Hb) …
circulatory system. To this end, the interactions between the different hemoglobin (Hb) …
Prokineticin receptors in GtoPdb v. 2023.1
R Hills, AJ Pawson, P Rondard, O Sbai… - IUPHAR/BPS Guide to …, 2023 - journals.ed.ac.uk
Prokineticin receptors, PKR 1 and PKR 2 (provisional nomenclature as recommended by
NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 …
NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 …