A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to
be significantly elevated in gastric cancer (GC) and may be associated with the proliferation …

Background Recent studies highlight pseudogene derived long non-coding RNAs
(lncRNAs) as key regulators of cancer biology. However, few of them have been well …

During early cortical development, neural stem cells (NSCs) divide symmetrically to expand
the progenitor pool, whereas, in later stages, NSCs divide asymmetrically to self-renew and …

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to
terminally differentiated neurons with exquisite spatio-temporal precision. Lineage …

Developmental progression depends on temporally defined changes in gene expression
mediated by transient exposure of lineage intermediates to signals in the progenitor niche …

Epigenetic modifiers are increasingly being investigated as potential therapeutics to modify
and overcome disease phenotypes. Diseases of the nervous system present a particular …

Chromatin regulation is a key process in development but its contribution to the evolution of
animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which …

Highlights•Neuronal functions of the histone demethylases LSD1, Kdm6b, and
Kdm5c.•Evidence for potential non-enzymatic functions of the histone demethylases.• …