Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

The role of integrins in inflammation and angiogenesis

OJ Mezu-Ndubuisi, A Maheshwari - Pediatric research, 2021 - nature.com
Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α)
and beta (β) subunits arranged in numerous dimeric pairings. These complexes have …

Acute inflammation in tissue healing

AM Soliman, DR Barreda - International Journal of Molecular Sciences, 2022 - mdpi.com
There are well-established links between acute inflammation and successful tissue repair
across evolution. Innate immune reactions contribute significantly to pathogen clearance …

Targeting neutrophils for promoting the resolution of inflammation

JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

[HTML][HTML] Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote …

B Yuan, H Chen, R Zhao, X Deng, G Chen, X Yang… - Bioactive materials, 2022 - Elsevier
The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key
factors for promoting the large-scale clinical application of magnesium (Mg)-based implants …

Neutrophils in acute inflammation: current concepts and translational implications

A Margraf, CA Lowell, A Zarbock - Blood, The Journal of the …, 2022 - ashpublications.org
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

J Ma, K Wei, J Liu, K Tang, H Zhang, L Zhu… - Nature …, 2020 - nature.com
Our current understanding of how sugar metabolism affects inflammatory pathways in
macrophages is incomplete. Here, we show that glycogen metabolism is an important event …

Transcatheter aortic valve implantation represents an anti-inflammatory therapy via reduction of shear stress–induced, piezo-1–mediated monocyte activation

S Baratchi, MTK Zaldivia, M Wallert, J Loseff-Silver… - Circulation, 2020 - Am Heart Assoc
Background: Aortic valve stenosis is an increasingly prevalent degenerative and
inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its …

Beta2-integrins and interacting proteins in leukocyte trafficking, immune suppression, and immunodeficiency disease

SC Fagerholm, C Guenther, M Llort Asens… - Frontiers in …, 2019 - frontiersin.org
Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for
leukocyte (eg, neutrophil, lymphocyte) trafficking, as well as for other immunological …

The fatal circle of NETs and NET-associated DAMPs contributing to organ dysfunction

H Block, J Rossaint, A Zarbock - Cells, 2022 - mdpi.com
The innate immune system is the first line of defense against invading pathogens or sterile
injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or …