Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

An important mediator of cytokine signaling implicated in regulation of hematopoiesis is the
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …

Each person's genome sequence has thousands of missense variants. Practical
interpretation of their functional significance must rely on computational inferences in the …

Hematopoietic stem cells (HSCs) possess unique gene expression programs that enforce
their identity and regulate lineage commitment. Long non-coding RNAs (lncRNAs) have …

Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary
arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point …

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative
therapy for patients suffering from hematological malignancies via the donor immune system …

The protein kinase Akt controls myriad signaling processes in cells, ranging from growth and
proliferation to differentiation and metabolism. Akt is activated by a combination of binding to …

Proteinaceous cysteine residues act as privileged sensors of oxidative stress. As reactive
oxygen and nitrogen species have been implicated in numerous pathophysiological …

Despite the many efforts already spent to enumerate somatic mutations in diffuse large B‐
cell lymphoma (DLBCL), previous whole‐genome and whole‐exome studies conducted on …

Inositide signaling pathways represent a multifaceted ensemble of cellular switches capable
of regulating a number of processes, for example, intracellular calcium release, membrane …