Fluorescent probes for lipid membranes: from the cell surface to organelles

AS Klymchenko - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Biomembranes are ubiquitous lipid structures that delimit the cell surface and
organelles and operate as platforms for a multitude of biomolecular processes. The …

Design and application of fluorescent probes to detect cellular physical microenvironments

J Ma, R Sun, K Xia, Q Xia, Y Liu, X Zhang - Chemical Reviews, 2024 - ACS Publications
The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …

Targeted solvatochromic fluorescent probes for imaging lipid order in organelles under oxidative and mechanical stress

DI Danylchuk, PH Jouard… - Journal of the American …, 2021 - ACS Publications
Biomembranes constitute a basis for all compartments of live cells, and therefore, the
monitoring of their lipid organization is essential for understanding cell status and activity …

Passive coupling of membrane tension and cell volume during active response of cells to osmosis

C Roffay, G Molinard, K Kim… - Proceedings of the …, 2021 - National Acad Sciences
During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …

Solvatochromic and fluorogenic dyes as environment-sensitive probes: design and biological applications

AS Klymchenko - Accounts of chemical research, 2017 - ACS Publications
Conspectus Fluorescent environment-sensitive probes are specially designed dyes that
change their fluorescence intensity (fluorogenic dyes) or color (eg, solvatochromic dyes) in …

A fluorescent membrane tension probe

A Colom, E Derivery, S Soleimanpour, C Tomba… - Nature …, 2018 - nature.com
Cells and organelles are delimited by lipid bilayers in which high deformability is essential to
many cell processes, including motility, endocytosis and cell division. Membrane tension is …

Mechanosensitive fluorescent probes to image membrane tension in mitochondria, endoplasmic reticulum, and lysosomes

A Goujon, A Colom, K Strakova, V Mercier… - Journal of the …, 2019 - ACS Publications
Measuring forces inside cells is particularly challenging. With the development of
quantitative microscopy, fluorophores which allow the measurement of forces became highly …

Conjugated polymers for assessing and controlling biological functions

E Zeglio, AL Rutz, TE Winkler, GG Malliaras… - Advanced …, 2019 - Wiley Online Library
The field of organic bioelectronics is advancing rapidly in the development of materials and
devices to precisely monitor and control biological signals. Electronics and biology can …

Fluorescent Flippers: Small‐Molecule Probes to Image Membrane Tension in Living Systems

XX Chen, F Bayard, N Gonzalez‐Sanchis… - Angewandte …, 2023 - Wiley Online Library
Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …

Dithienothiophenes at work: Access to mechanosensitive fluorescent probes, chalcogen-bonding catalysis, and beyond

K Strakova, L Assies, A Goujon, F Piazzolla… - Chemical …, 2019 - ACS Publications
In this review, the multifunctionality of dithieno [3, 2-b: 2′, 3′-d] thiophenes (DTTs) is
covered comprehensively. This is of interest because all involved research is very recent …