Immunotherapy of glioblastoma: current strategies and challenges in tumor model development
Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …
immunotherapy is playing an increasingly central role in the treatment of many cancers …
Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …
role in several processes—such as protein degradation, changes in cell signaling, cell …
Inability of ovarian cancers to upregulate their MHC-class I surface expression marks their aggressiveness and increased susceptibility to NK cell-mediated cytotoxicity
We extended our previous observations with other tumor models to study seven ovarian
tumor cell lines—OVCAR3, OVCAR4, OVCAR8, SKOV3, Kuramochi, OAW28, and CaOV3 …
tumor cell lines—OVCAR3, OVCAR4, OVCAR8, SKOV3, Kuramochi, OAW28, and CaOV3 …
an update on glioblastoma biology, genetics, and current therapies: Novel inhibitors of the g protein-coupled receptor CCR5
T Lah Turnšek, X Jiao, M Novak, S Jammula… - International journal of …, 2021 - mdpi.com
The mechanisms governing therapeutic resistance of the most aggressive and lethal primary
brain tumor in adults, glioblastoma, have increasingly focused on tumor stem cells. These …
brain tumor in adults, glioblastoma, have increasingly focused on tumor stem cells. These …
The potential role of cytotoxic immune effectors in induction, progression and pathogenesis of amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is an auto-immune neurodegenerative disorder affecting
the motor-neuron system. The causes of ALS are heterogeneous, and are only partially …
the motor-neuron system. The causes of ALS are heterogeneous, and are only partially …
Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas
High-grade serous ovarian cancers (HGSOCs) likely consist of poorly differentiated stem-
like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable …
like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable …
Cathepsin X activity does not affect NK-target cell synapse but is rather distributed to cytotoxic granules
T Jakoš, M Prunk, A Pišlar, J Kos - International journal of molecular …, 2021 - mdpi.com
Cathepsin X is a lysosomal peptidase that is involved in tumour progression and represents
a potential target for therapeutic interventions. In addition, it regulates important functions of …
a potential target for therapeutic interventions. In addition, it regulates important functions of …
Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro
Despite advancements in the field of cancer therapeutics, the five-year survival rate remains
low in oral cancer patients. Therefore, the effective therapeutics are needed against oral …
low in oral cancer patients. Therefore, the effective therapeutics are needed against oral …
Supercharged NK Cell-Based Immuotherapy in Humanized Bone Marrow Liver and Thymus (Hu-BLT) Mice Model of Oral, Pancreatic, Glioblastoma, Hepatic …
In this paper, we review a number of in vitro and in vivo studies regarding the efficacy of
supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have …
supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have …