Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

Emerging preclinical and clinical evidence indicate that the lateral habenula plays a major
role in the pathophysiology of depressive illness. Aberrant increases in neuronal activity in …

Prolonged behavioral challenges can cause animals to switch from active to passive coping
strategies to manage effort-expenditure during stress; such normally adaptive behavioral …

In this Perspective review, we highlight some of the less explored aspects of lateral
habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide …

The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase
and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability …

Background The role of the amygdala in mediating stress coping has been long
appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized …

In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

The lateral habenula (LHb) encodes aversive states, and its dysregulation is implicated in
neuropsychiatric disorders, including depression. The endocannabinoid (eCB) system is a …

The lateral habenula (LHb) is an epithalamic brain region associated with value-based
decision making and stress evasion through its modulation of dopamine (DA)-mediated …

Mounting evidence suggests that the long-term effects of adverse early life stressors on
vulnerability to drug addiction and mood disorders are related to dysfunction of brain …