A GSH-resistant FK228 analogue containing a stable disulfide bond
M Zhan, Y Xing, Z Li, F Yin - Bioorganic Chemistry, 2024 - Elsevier
FK228 is a potent natural pan HDAC inhibitor approved by the FDA for the treatment of
cutaneous T-cell lymphoma as well as peripheral T-cell lymphoma. It is generally believed …
cutaneous T-cell lymphoma as well as peripheral T-cell lymphoma. It is generally believed …
Design, Synthesis, and Biological Evaluation of New Urushiol Derivatives as Potent Class I Histone Deacetylase Inhibitors
H Zhou, Z Qi, D Liu, X Xue, C Wang - ChemBioChem, 2023 - Wiley Online Library
In the present study, a novel series of 11 urushiol‐based hydroxamic acid histone
deacetylase (HDAC) inhibitors was designed, synthesized, and biologically evaluated …
deacetylase (HDAC) inhibitors was designed, synthesized, and biologically evaluated …
Regio-and stereoselective ring contraction of 1, 2-dithianes to 1, 2-dithiolanes
TS Mansour, CA Evans, DE Bogucki, S Chowdhury - Tetrahedron Letters, 2023 - Elsevier
Abstract Monobenzoylated 1, 2-dithiane-4, 5 diols undergo a novel ring contraction reaction
under Mitsunobu conditions to produce 3, 4-disubstituted 1, 2-dithiolanes. This …
under Mitsunobu conditions to produce 3, 4-disubstituted 1, 2-dithiolanes. This …
Unmasking latent thioesters under hydrophobic‐compatible conditions
WS Perkins, RT Davison, GB Shelkey… - Journal of Peptide …, 2021 - Wiley Online Library
Hydrophobic latent C‐terminal thioesters were converted into thioesters, and were also
coupled with cysteine in one‐pot reactions, using conditions generally compatible with …
coupled with cysteine in one‐pot reactions, using conditions generally compatible with …