Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Serine, glycine and other nonessential amino acids are critical for tumour progression, and
strategies to limit their availability are emerging as potential therapies for cancer,–. However …

Background Identifying mechanisms of diseases with complex inheritance patterns, such as
macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
motor neurons. Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT), which …

HSAN1 is an inherited neuropathy found to be associated with several missense mutations
in the SPTLC1 subunit of serine palmitoyltransferase (SPT). SPT catalyzes the condensation …

Sphingolipids comprise a complex family of naturally occurring molecules that are enriched
in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids …

A new review covering up to 2018 Sphingolipids are essential molecules that, despite their
long history, are still stimulating interest today. The reasons for this are that, as well as …

Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …