[HTML][HTML] Immunogenicity to biotherapeutics–the role of anti-drug immune complexes
M Krishna, SG Nadler - Frontiers in immunology, 2016 - frontiersin.org
Biological molecules are increasingly becoming a part of the therapeutics portfolio that has
been either recently approved for marketing or those that are in the pipeline of several …
been either recently approved for marketing or those that are in the pipeline of several …
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
JC Holter, SE Pischke, E de Boer… - Proceedings of the …, 2020 - National Acad Sciences
Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
Complement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugs
Liposomes are known to activate the complement (C) system, which can lead in vivo to a
hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has …
hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has …
[HTML][HTML] Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Gelatin based adhesives have been used in the last decades in different biomedical
applications due to the excellent biocompatibility, easy processability, transparency, non …
applications due to the excellent biocompatibility, easy processability, transparency, non …
[HTML][HTML] Age and sex-associated changes of complement activity and complement levels in a healthy Caucasian population
Introduction: The complement system is essential for an adequate immune response. Much
attention has been given to the role of complement in disease. However, to better …
attention has been given to the role of complement in disease. However, to better …
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce
adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are …
adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are …
[HTML][HTML] The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection
F Askarian, S Uchiyama, H Masson… - Nature …, 2021 - nature.com
The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave
polysaccharides by oxidation, have been associated with bacterial virulence, but supporting …
polysaccharides by oxidation, have been associated with bacterial virulence, but supporting …
[HTML][HTML] Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
N Niyonzima, SS Bakke, I Gregersen, S Holm… - …, 2020 - thelancet.com
Background During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in
the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD …
the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD …
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
RS Keshari, R Silasi, NI Popescu… - Proceedings of the …, 2017 - National Acad Sciences
Bacterial sepsis triggers robust activation of the complement system with subsequent
generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that …
generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that …
[HTML][HTML] Inflammatory response after laparoscopic versus open resection of colorectal liver metastases: data from the Oslo-CoMet trial
Inflammatory Response After Laparoscopic Versus Open Resecti... : Medicine Inflammatory
Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data …
Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data …