The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic
microbial cells. The microbiota, the gut, and the brain form an association,'the microbiota-gut …

The gut microbiota comprises a complex community of microorganism species that resides
in our gastrointestinal ecosystem and whose alterations influence not only various gut …

Objective Gut microbiota changes before the onset of Alzheimer's disease (AD) and the
alterations could be detected in the stage of mild cognitive impairment (MCI). The findings …

Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

The regulation of physiological gut functions such as peristalsis or secretion of digestive
enzymes by the central nervous system via the Nervus vagus is well known. Recent …

The Pearson correlation coefficient (PCC) and the Mander's overlap coefficient (MOC) are
used to quantify the degree of colocalization between fluorophores. The MOC was …

Background Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to
pathogenesis and pathology of vascular-based neurodegenerative disorders such as …

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo
systems for therapeutic drug development and investigating disease pathophysiology …

In recent years, emerging studies have observed gut microbiota (GM) alterations in
Alzheimer's disease (AD), even in individuals with mild cognitive impairment (MCI). Further …