Heterotrimeric G proteins in vertebrates constitute a family molecular switches that transduce
the activation of a populous group of cell-surface receptors to a group of diverse effector …

Many potentially valuable techniques for the understanding of human neurobiological and
neuropathological processes require the use of RNA obtained from postmortem tissue. As …

Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …

Postmortem human brain tissue is used for the study of many different brain diseases. A key
factor in conducting postmortem research is the quality of the tissue. Unlike animal tissue …

Postmortem analysis of brains of patients with Alzheimer's disease (AD) has led to diverse
theories about the causes of the pathology, suggesting that this complex disease involves …

To help account for the variable quality and quantity of RNA in human brain, we have
studied the effect of premortem (agonal state) and postmortem factors on the detection of …

Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse
formation, plasticity, and metabolism. Astrocyte dysfunction may disrupt their normal role …

Brain banks are facilities providing an interface between generous donation of nervous
tissues and research laboratories devoted to increase our understanding of the diseases of …

The quantification of mRNA in postmortem human brain is often made complicated by
confounding factors. To assess the importance of potential confounders TaqMan™ real-time …

The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and
physiological analyses is reviewed. RNA and protein samples have been found suitable for …