Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
[HTML][HTML] Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation
JL Hyde, MS Diamond - Virology, 2015 - Elsevier
Abstract N-7 and 2′-O methylation of host cell mRNA occurs in the nucleus and results in
the generation of cap structures (cap 0, m 7 GpppN; cap 1, m 7 GpppNm) that control gene …
the generation of cap structures (cap 0, m 7 GpppN; cap 1, m 7 GpppNm) that control gene …
[HTML][HTML] Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
human infections, and an effective vaccine is critical to mitigate coronavirus-induced disease …
human infections, and an effective vaccine is critical to mitigate coronavirus-induced disease …
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I
Abstract Internal N 6-methyladenosine (m6A) modification is one of the most common and
abundant modifications of RNA. However, the biological roles of viral RNA m6A remain …
abundant modifications of RNA. However, the biological roles of viral RNA m6A remain …
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the main target for neutralizing antibodies (NAbs). The S protein trimer is anchored in the …
the main target for neutralizing antibodies (NAbs). The S protein trimer is anchored in the …
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
5-methylcytosine (m5C) is one of the most prevalent modifications of RNA, playing important
roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA …
roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA …
Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection
W McIntyre, R Netzband, G Bonenfant… - Nucleic Acids …, 2018 - academic.oup.com
More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …
Coronavirus non-structural protein 16: evasion, attenuation, and possible treatments
VD Menachery, K Debbink, RS Baric - Virus research, 2014 - Elsevier
The recent emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV),
nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the …
nearly a decade after the Severe Acute Respiratory Syndrome (SARS) CoV, highlights the …
A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
Current efforts to develop Zika virus (ZIKV) subunit vaccines have been focused on pre-
membrane (prM) and envelope (E) proteins, but the role of NS1 in ZIKV-specific immune …
membrane (prM) and envelope (E) proteins, but the role of NS1 in ZIKV-specific immune …
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals
MD Daugherty, AM Schaller, AP Geballe, HS Malik - Elife, 2016 - elifesciences.org
IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of
mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O …
mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O …