Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of
mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …

The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein
synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation …

Dynamic regulation of mRNA translation initiation and elongation is essential for the survival
and function of neural cells. Global reductions in translation initiation resulting from …

The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that
mTOR/S6K signaling contributes to several pathological conditions, such as diabetes …

Milk has been recognized to represent a functionally active nutrient system promoting
neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase …

The original purification of the heterotrimeric eIF4F was published over 30 years ago (Grifo,
JA, Tahara, SM, Morgan, MA, Shatkin, AJ, and Merrick, WC (1983) J. Biol. Chem. 258, 5804 …

Protein synthesis and degradation are dynamically regulated processes that act in concert to
control the accretion or loss of muscle mass. The present article focuses on the mechanisms …