[HTML][HTML] Emerging diabetes therapies: Bringing back the β-cells
Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …
Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system
C Rosselot, Y Li, P Wang, A Alvarsson… - Science Translational …, 2024 - science.org
Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β
cells are reduced in number in most people with diabetes, but most individuals still have …
cells are reduced in number in most people with diabetes, but most individuals still have …
Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy
Z Huan, J Li, Z Luo, Y Yu, L Li - Research, 2024 - spj.science.org
Islet transplantation has now become a promising treatment for insulin-deficient diabetes
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …
[HTML][HTML] HNF1α maintains pancreatic α and β cell functions in primary human islets
HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes
(HNF1A–maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A …
(HNF1A–maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A …
Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin
S Bornstein, I Shapiro, M Malyukov, R Züllig… - Cell Death & …, 2022 - nature.com
The adrenal gland provides an important function by integrating neuronal, immune,
vascular, metabolic and endocrine signals under a common organ capsule. It is the central …
vascular, metabolic and endocrine signals under a common organ capsule. It is the central …
Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy
J Yang, Y Yan, X Yin, X Liu, IV Reshetov, PA Karalkin… - Metabolism, 2024 - Elsevier
Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid
technologies have rapidly advanced, leading to the emergence of bioengineering islet …
technologies have rapidly advanced, leading to the emergence of bioengineering islet …
[HTML][HTML] Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
Successful genome editing in primary human islets could reveal features of the genetic
regulatory landscape underlying β cell function and diabetes risk. Here, we describe a …
regulatory landscape underlying β cell function and diabetes risk. Here, we describe a …
Microwell culture platform maintains viability and mass of human pancreatic islets
H Kato, T Miwa, J Quijano, L Medrano, J Ortiz… - Frontiers in …, 2022 - frontiersin.org
Background Transplantation of the human pancreatic islets is a promising approach for
specific types of diabetes to improve glycemic control. Although effective, there are several …
specific types of diabetes to improve glycemic control. Although effective, there are several …
CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets
X Wu, PI Chen, RL Whitener, MS MacDougall… - Frontiers in …, 2024 - frontiersin.org
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes
to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of …
to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of …