Coenzyme Q (CoQ) is a remarkably hydrophobic, redox-active lipid that empowers diverse
cellular processes. Although most known for shuttling electrons between mitochondrial …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor composed of a redox-active
quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access …

Mitochondria critically rely on protein import and its tight regulation. Here, we found that the
complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and …

Intervertebral disc degeneration (IDD) is the most critical pathological factor in the
development of low back pain. The maintenance of nucleus pulposus (NP) cell and …

We describe deep analysis of the human proteome in less than 1 h. We achieve this
expedited proteome characterization by leveraging state-of-the-art sample preparation …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …