This review provides a comprehensive overview of the established and emerging roles that
organelles play in calcium signalling. The function of calcium as a secondary messenger in …

The mitochondrial carriers (MC) constitute a large family (MCF) of inner membrane
transporters displaying different substrate specificities, patterns of gene expression and …

Calcium signalling is fundamental to the function of the nervous system, in association with
changes in ionic gradients across the membrane. Although restoring ionic gradients is …

Mitochondria in malaria parasites have some unusual evolutionary and functional features.
The drastic reduction in the size of their mitochondrial genome, encoding just three proteins …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

The mitochondrial genome (mtDNA) is required for normal cellular function; inherited and
somatic mutations in mtDNA lead to a variety of diseases. Saccharomyces cerevisiae has …

Despite extensive research, the regulation of mitochondrial function is still not understood
completely. Ample evidence shows that cytosolic Ca2+ has a strategic task in co-ordinating …

Iron is essential for life. Its coordinated distribution between intracellular compartments and
the adaptation of iron uptake to intracellular demands are central for a balanced iron …

To date, 22 mitochondrial carrier subfamilies have been functionally identified based on
substrate specificity. Structural, functional and bioinformatics studies have pointed to the …

Ca 2+-mediated mitochondrial permeability transition (mPT) is the final common pathway of
stress-induced cell death in many major pathologies, but its regulation in intact cells is …