Exosomes regulate cell behavior by binding to and delivering their cargo to target cells;
however, the mechanisms mediating exosome-cell interactions are poorly understood …

Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the
clonal proliferation of malignant plasma cells (PCs) within the bone marrow. Clonal …

Multiple myeloma (MM) remains incurable despite the abundance of novel drugs. As it has
been previously shown, preclinical 2D models fail to predict disease progression due to their …

Multiple myeloma (MM) is the second most common hematological malignancy,
characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal …

PURPOSE Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations.
The overall goal of this study was to describe the genomic landscape of myeloma using …

Epigenetic alterations have been previously shown to contribute to multiple myeloma (MM)
pathogenesis via DNA methylations and histone modifications. RNA methylation, a novel …

Cell-cell communication mediates immune responses to physiological stimuli at local and
systemic levels. Intercellular communication occurs via a direct contact between cells as well …

Multiple myeloma (MM) is an incurable malignancy of bone marrow plasma cells
characterized by wide clinical and molecular heterogeneity. In this study we applied an …

Splicing changes are common in cancer and are associated with dysregulated splicing
factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma …

Clonal evolution drives tumor progression, dissemination, and relapse in multiple myeloma
(MM), with most patients dying of relapsed disease. This multistage process requires tumor …