Background Substantial amounts of public funds are invested in health research worldwide.
Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower …

Introduction Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated
diarrhea. CDI has increased in incidence and severity over the past decade, and is a …

Clostridioides difficile infection occurs when the bacterium produces toxin that causes
diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to …

Antibiotic-associated diarrhea (AAD) and Clostridum difficile infections (CDI) have been well
studied for adult cases, but not as well in the pediatric population. Whether the disease …

The species composition of the human gut microbiota is related to overall health, and a
healthy gut microbiome is crucial in maintaining colonization resistance against pathogens …

Antibiotics, as one of the emerging pollutants, are non-biodegradable compounds and long-
term exposure to them may affect endocrine, hormonal, and genetic systems of human …

Clostridium difficile is a leading cause of antibiotic-associated diarrhea worldwide. The
diagnosis of C. difficile infection (CDI) requires both clinical manifestations and a positive …

Agents in development for the prevention or treatment of Clostridioides difficile infection can
be split into three broad categories: antibiotics, microbiome restoration, and vaccines. Given …

Clostridium difficile infections are a global clinical concern and are one of the leading
causes of nosocomial outbreaks. Preventing these infections has benefited from …

Elderly people are an important part of the global population who suffer from the natural
processes of senescence, which lead to changes in the gut microbiota composition. These …