The biological compositions including cells, proteins/peptides, nucleic acids, extracellular
vesicles (EVs) and metabolites are no doubt closely related to almost all physiological and …

In vitro diagnosis (IVD) is pivotal in modern medicine, enabling early disease detection and
treatment optimization. Omics technologies, particularly proteomics and metabolomics, offer …

Protein glycosylation and phosphorylation are two important protein post-translational
modifications. Mass spectrometry (MS) has been proved to be a powerful technique in …

The heterogeneous populations of exosomes with distinct nanosize have impeded our
understanding of their corresponding function as intercellular communication agents …

The flexible and controlled synthesis of metal–organic framework (MOF)-derived hybrid
nanostructures is of great significance in fine tuning of their enrichment performance in large …

In this work, a magnetic covalent organic framework (COF) with inherent hydrophilicity
(denoted mCTpBD) was synthesized through interface deposition of a hydrophilic COF shell …

Human health is always under global spotlight, but now it suffers from severe environmental
issue and various diseases. Developing highly selective and effective extraction technique …

Performing reactions under physiologically relevant conditions often challenges the
catalysts' robustness, reactivity and recyclability. Widely regarded as stable and versatile …

Owing to the formidable challenge posed by microheterogeneities in glycosylation sites,
macroheterogeneity of the modification number of glycans, and low abundance and …

Endogenous glycopeptides have been confirmed to play a significant role in multifarious
pathological and physiological processes. The low abundance of endogenous …