Advanced nitric oxide generating nanomedicine for therapeutic applications

Z Wang, A Jin, Z Yang, W Huang - ACS nano, 2023 - ACS Publications
Nitric oxide (NO), a gaseous transmitter extensively present in the human body, regulates
vascular relaxation, immune response, inflammation, neurotransmission, and other crucial …

Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing

M Wu, Z Lu, K Wu, C Nam, L Zhang… - Journal of Materials …, 2021 - pubs.rsc.org
Chronic wounds, such as pressure ulcers, vascular ulcers and diabetic foot ulcers (DFUs),
often stay in a state of pathological inflammation and suffer from persistent infection, excess …

Opportunities for nitric oxide in potentiating cancer immunotherapy

J Kim, SN Thomas - Pharmacological Reviews, 2022 - ASPET
Despite nearly 30 years of development and recent highlights of nitric oxide (NO) donors
and NO delivery systems in anticancer therapy, the limited understanding of exogenous …

Nitric oxide releasing nanomaterials for cardiovascular applications

TA Tabish, MJ Crabtree, HE Townley… - Basic to Translational …, 2024 - jacc.org
A central paradigm of cardiovascular homeostasis is that impaired nitric oxide (NO)
bioavailability results in a wide array of cardiovascular dysfunction including incompetent …

[HTML][HTML] Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue

L Yan, L Wang, J Wu, Y Wu, X Zhu, Q Mei… - NPJ Regenerative …, 2022 - nature.com
In this study, we successfully constructed the new graphene oxide/poly-L-lactic acid
(GO/PLLA) nanofiber scaffolds with a hydrophilic surface and porous network structure that …

[HTML][HTML] Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?

JC Pieretti, MT Pelegrino, MHM Nascimento… - Biochemical …, 2020 - Elsevier
Nitric oxide (NO) is an endogenous free radical that controls important physiological and
pathophysiological processes, including a role in cancer biology. NO can have a direct toxic …

[HTML][HTML] Bimodal modulation of in vitro angiogenesis with photoactive polymer nanoparticles

G Tullii, E Gutierrez-Fernandez, C Ronchi… - Nanoscale, 2023 - pubs.rsc.org
Angiogenesis is a fundamental process in biology, given the pivotal role played by blood
vessels in providing oxygen and nutrients to tissues, thus ensuring cell survival. Moreover, it …

Weibull β value for the discernment of drug release mechanism of PLGA particles

U de Jesús Martín-Camacho… - International Journal of …, 2023 - Elsevier
Mathematical models are used to characterize and optimize drug release in drug delivery
systems (DDS). One of the most widely used DDS is the poly (lactic-co-glycolic acid)(PLGA) …

Nitric oxide and immune responses in cancer: Searching for new therapeutic strategies

A Sahebnasagh, F Saghafi, S Negintaji… - Current medicinal …, 2022 - ingentaconnect.com
In recent years, there has been an increasing interest in understanding the mysterious
functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to …

[HTML][HTML] CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

D Szukiewicz - International journal of molecular sciences, 2024 - mdpi.com
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties
resulting from the combination of chemoattractants and adhesion molecules. The soluble …