Melanoma represents the most aggressive and the deadliest form of skin cancer. Current
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …

Genomic profiling shows that many solid tumors are characterized by specific driver
aberrations, and this has expanded the therapeutic options for many patients. The mitogen …

Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die
within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung …

Most tumor cells express antigens that can mediate recognition by host CD8+ T cells.
Cancers that are detected clinically must have evaded antitumor immune responses to grow …

Targeted therapies are substantially changing the management of lung cancers. These
treatments include drugs that target driver mutations, those that target presumed important …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

The identification of driver oncogenes has provided important targets for drugs that can
change the landscape of cancer therapies. One such example is the BRAF oncogene, which …

Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

Background Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose
underlying genetic lesion is still obscure. Methods We searched for HCL-associated …