This review discusses recent advances in our understanding of the role filopodia and
filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in …

The vasculature is one of the most dynamic tissues that encounter numerous mechanical
cues derived from pulsatile blood flow, blood pressure, activity of smooth muscle cells in the …

The development and maintenance of tissues requires collective cell movement, during
which neighbouring cells coordinate the polarity of their migration machineries. Here, we …

Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the
endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the …

How vascular tubes build, maintain and adapt continuously perfused lumens to meet local
metabolic needs remains poorly understood. Recent studies showed that blood flow itself …

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …

Endothelial cell–cell junctions maintain a restrictive barrier that is tightly regulated to allow
dynamic responses to permeability-inducing angiogenic factors, as well as to inflammatory …

The morpholino anti-sense technology has been used extensively to test gene function. The
zebrafish model allows a detailed comparison of knockdown (anti-sense) and knockout …

Endothelial cell–cell junctions must perform seemingly incompatible tasks during vascular
development—providing stable connections that prevent leakage, while allowing dynamic …

Angiogenesis is a dynamic process relying on endothelial cell rearrangements within
vascular tubes, yet the underlying mechanisms and functional relevance are poorly …