Anthraquinones are privileged chemical scaffolds that have been used for centuries in
various therapeutic applications. The anthraquinone moiety forms the core of various …

Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Abstract Selenium-containing quinone-based 1, 2, 3-triazoles were synthesized using click
chemistry, the copper catalyzed azide-alkyne 1, 3-dipolar cycloaddition, and evaluated …

Abstract Naphthalene-1, 4-dione derivatives were synthesized and tested against selected
bacterial strains. All the tested compounds were prepared by direct introduction of …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Survivin is a novel attractive target for cancer therapy; however, it is considered undruggable
because it lacks enzymatic activities. Herein, we describe our efforts toward the discovery of …

We report a Rh-catalyzed method for the C-5 selective C–H iodination of naphthoquinones
and show that complementary C-2 selective processes can be achieved under related …

Abstract Morita-Baylis-Hillman acetates and α-bromonitroalkenes have been employed in
cascade reactions with lawsone and 2-aminonaphthoquinone for the one-pot synthesis of …

Quinonoid compounds based on 5-iodo-1, 4-disubstituted-, 1, 4-and 1, 5-disubstituted-1, 2,
3-triazoles were synthesized using simple methodologies and evaluated against T. cruzi, the …

Indoleamine-2, 3-dioxygenase 1 (IDO1) and signal transducer and activator of transcription
3 (STAT3) are important targets in the tumor microenvironment for cancer therapy. In the …