Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19
Animal models that can replicate clinical and pathologic features of severe human
coronavirus infections have been instrumental in the development of novel vaccines and …
coronavirus infections have been instrumental in the development of novel vaccines and …
Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA. 2/5 subvariants in the upper and lower respiratory tract
Summary Background Earlier Omicron subvariants including BA. 1, BA. 2, and BA. 5
emerged in waves, with a subvariant replacing the previous one every few months. More …
emerged in waves, with a subvariant replacing the previous one every few months. More …
SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …
well described, although whether such attenuation is retained for later variants like BA. 5 …
Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN. 1 and other variants
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued
antigenic diversification and resulting emergence of new variants. By increasing herd …
antigenic diversification and resulting emergence of new variants. By increasing herd …
[HTML][HTML] Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody
Since its emergence, SARS-CoV-2 has been continuously evolving, hampering the
effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at …
effectiveness of current vaccines against COVID-19. mAbs can be used to treat patients at …
[HTML][HTML] Tissue-resident memory T cells contribute to protection against heterologous SARS-CoV-2 challenge
A Odle, M Kar, AK Verma, A Sariol, DK Meyerholz… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
New vaccine formulations are based on circulating strains of virus, which have tended to
evolve to more readily transmit human to human and to evade the neutralizing antibody …
evolve to more readily transmit human to human and to evade the neutralizing antibody …
Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19
CN Baker, D Duso, N Kothapalli, T Hart, S Casey… - Scientific Reports, 2024 - nature.com
Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range
beyond primates, and a few other mammals, to mice, affording the opportunity to exploit …
beyond primates, and a few other mammals, to mice, affording the opportunity to exploit …
Berbamine prevents SARS-CoV-2 entry and transmission
S Sadhu, S Goswami, R Khatri, B Lohiya, V Singh… - iScience, 2024 - cell.com
Effective antiviral drugs are essential to combat COVID-19 and future pandemics. Although
many compounds show antiviral in vitro activity, only a few retain effectiveness in vivo …
many compounds show antiviral in vitro activity, only a few retain effectiveness in vivo …
Omicron BA. 5 infects human brain organoids and is neuroinvasive and lethal in K18-hACE2 mice
R Stewart, SA Ellis, K Yan, T Dumenil, B Tang… - bioRxiv, 2022 - biorxiv.org
ABSTRACT A frequently repeated premise is that viruses evolve to become less pathogenic.
This appears also to be true for SARS-CoV-2, although the increased level of immunity in …
This appears also to be true for SARS-CoV-2, although the increased level of immunity in …
Increased neurovirulence of omicron BA. 5 over BA. 1 in human brain organoids and K18-hACE2 mice
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …
well described, although whether such attenuation is retained for later variants like BA. 5 …