Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

Chronic granulomatous disease (CGD) is a rare inherited disorder of phagocytic cells,. We
report the initial results of nine severely affected X-linked CGD (X-CGD) patients who …

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …

The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient
antimicrobial defense system against microorganisms. The NADPH oxidases (NOX), which …

Pioneering gene therapy trials have shown that the genetic engineering of haematopoietic
stem and progenitor cells can be an alternative to allogeneic transplantation in the treatment …

Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies,
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens …

Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is
the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor …

Sickle cell disease is characterized by chronic anemia and vaso-occlusive crises, which
eventually lead to multi-organ damage and premature death. Hematopoietic stem cell …