From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases
E Cano-Gamez, G Trynka - Frontiers in genetics, 2020 - frontiersin.org
Genome-wide association studies (GWAS) have successfully mapped thousands of loci
associated with complex traits. These associations could reveal the molecular mechanisms …
associated with complex traits. These associations could reveal the molecular mechanisms …
Using genetic data to strengthen causal inference in observational research
Causal inference is essential across the biomedical, behavioural and social sciences. By
progressing from confounded statistical associations to evidence of causal relationships …
progressing from confounded statistical associations to evidence of causal relationships …
Use of Lipoprotein (a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association
DP Wilson, TA Jacobson, PH Jones… - Journal of clinical …, 2019 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a well-recognized, independent risk factor for
atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in …
atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in …
Association between obesity and cardiovascular outcomes: a systematic review and meta-analysis of Mendelian randomization studies
Importance Although dyslipidemia has been consistently shown to be associated with
atherogenesis, an association between obesity and cardiovascular disease outcomes …
atherogenesis, an association between obesity and cardiovascular disease outcomes …
China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
Z Chen, J Chen, R Collins, Y Guo… - International journal …, 2011 - academic.oup.com
Background Large blood-based prospective studies can provide reliable assessment of the
complex interplay of lifestyle, environmental and genetic factors as determinants of chronic …
complex interplay of lifestyle, environmental and genetic factors as determinants of chronic …
[图书][B] The dyslexia debate
JG Elliott, EL Grigorenko - 2014 - books.google.com
The Dyslexia Debate examines how we use the term" dyslexia" and questions its efficacy as
a diagnosis. While many believe that a diagnosis of dyslexia will shed light on a reader's …
a diagnosis. While many believe that a diagnosis of dyslexia will shed light on a reader's …
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
HB El–Serag, KL Rudolph - Gastroenterology, 2007 - Elsevier
Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …
the fifth most common cancer worldwide and the third most common cause of cancer …
[图书][B] A dictionary of epidemiology
MS Porta, S Greenland, M Hernán, I dos Santos Silva… - 2014 - books.google.com
This sixth edition of A Dictionary of Epidemiology--the most updated since its inception--
reflects the profound substantive and methodological changes that have come to …
reflects the profound substantive and methodological changes that have come to …
Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology
BG Nordestgaard, A Langsted - Journal of lipid research, 2016 - ASBMB
Human epidemiologic and genetic evidence using the Mendelian randomization approach
in large-scale studies now strongly supports that elevated lipoprotein (a)[Lp (a)] is a causal …
in large-scale studies now strongly supports that elevated lipoprotein (a)[Lp (a)] is a causal …
Mendelian randomization as an instrumental variable approach to causal inference
In epidemiological research, the causal effect of a modifiable phenotype or exposure on a
disease is often of public health interest. Randomized controlled trials to investigate this …
disease is often of public health interest. Randomized controlled trials to investigate this …