Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

Toll-like receptors (TLRs) are a group of receptors widely distributed in the organism. In the
central nervous system, they are expressed in neurons, astrocytes and microglia. Although …

Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …

Alzheimer's disease (AD) is a progressive neurogenerative disorder manifested by gradual
memory loss and cognitive decline due to profound damage of cholinergic neurons. The …

Toll‐like receptors mediate important cellular immune responses upon activation via various
pathogenic stimuli such as bacterial or viral components. The activation and subsequent …

Neuroinflammation and microglial dysfunction are key contributors to the development of
Alzheimer's disease (AD). Toll-like receptors (TLRs) are transmembrane proteins primarily …

As cognitive impairments continue to rise in prevalence, there is an urgent need to
understand the mechanisms of learning and memory in normal and disordered states. C–C …

Genome-wide association studies identified the BIN1 locus as a leading modulator of
genetic risk in Alzheimer's disease (AD). One limitation in understanding BIN1's contribution …

The pathophysiological processes of dementia and cognitive impairment are linked to
advanced glycation end products (AGEs) and their receptor (RAGE). The neurofibrillary …