Advancements in inhibitors of crucial enzymes in the cysteine biosynthetic pathway: Serine acetyltransferase and O‐acetylserine sulfhydrylase
Y Qin, Y Teng, Y Yang, Z Mao, S Zhao… - Chemical Biology & …, 2024 - Wiley Online Library
Infectious diseases have been jeopardized problem that threaten public health over a long
period of time. The growing prevalence of drug‐resistant pathogens and infectious cases …
period of time. The growing prevalence of drug‐resistant pathogens and infectious cases …
Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors
R Vijayan, S Gourinath - Journal of proteins and proteomics, 2021 - Springer
Coronaviruses are enveloped, non-segmented positive-sense RNA viruses with the largest
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
Reactive oxygen species-dependent anti-extended spectrum β-lactamases activity of multi-layer Ti3C2Tx: A novel approach for treating successfully P. aeruginosa …
G Rajivgandhi, MM Margoni, CK Chelliah… - Chemical Engineering …, 2024 - Elsevier
Abstract Multi-layer (ML) Ti 3 C 2 T x was investigated regarding its anti-extended spectrum
β-lactamases (ESBLs) activity and in-vivo toxicity. Powder X-ray diffraction of ML-Ti 3 C 2 T x …
β-lactamases (ESBLs) activity and in-vivo toxicity. Powder X-ray diffraction of ML-Ti 3 C 2 T x …
[PDF][PDF] Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis
K Sowerby, S Freitag-Pohl, AM Murillo… - … Section D: Structural …, 2023 - journals.iucr.org
Chagas disease is a neglected tropical disease (NTD) caused by Trypanosoma cruzi, whilst
leishmaniasis, which is caused by over 20 species of Leishmania, represents a group of …
leishmaniasis, which is caused by over 20 species of Leishmania, represents a group of …
Pyridoxal kinase gene deletion leads to impaired growth, deranged redox metabolism and cell cycle arrest in Leishmania donovani
Pyridoxal kinase (PdxK) is a vitamin B 6 salvage pathway enzyme which produces pyridoxal
phosphate. We have investigated the impact of PdxK deletion in Leishmania donovani on …
phosphate. We have investigated the impact of PdxK deletion in Leishmania donovani on …
Characterization and functional insights into the Entamoeba histolytica pyridoxal kinase, an enzyme essential for its survival
Abstract Pyridoxal 5′-phosphate (PLP) is the active form of vitamin B 6 and a cofactor for
more than 140 enzymes. This coenzyme plays a pivotal role in catalysis of various …
more than 140 enzymes. This coenzyme plays a pivotal role in catalysis of various …
Prediction of potential cysteine synthase inhibitors of Leishmania braziliensis and Leishmania major parasites by computational screening
J Téllez, A Amarillo, C Suarez, C Cardozo, D Guerra… - Acta Tropica, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease considered a public health problem that
requires innovative strategies for its chemotherapeutic control. In the present investigation, a …
requires innovative strategies for its chemotherapeutic control. In the present investigation, a …
Structural and functional studies of serine acetyltransferase isoform from Entamoeba histolytica reveals novel role of the C-terminal tail in loss of regulation from …
S Dharavath, K Kumari, S Kumar… - International Journal of …, 2022 - Elsevier
Serine acetyltransferase (SAT) catalyzes the acetylation of l-serine in the first step of the two-
step pathway to synthesize L-cysteine in bacteria, protozoans and plants. L-cysteine is …
step pathway to synthesize L-cysteine in bacteria, protozoans and plants. L-cysteine is …
The Discovery of Potential MDM2 Inhibitors: A Combination of Pharmacophore Modeling, Virtual Screening, Molecular Docking Studies, and in vitro/in vivo …
X Zhang, C Zhou, Y Yang, H Liu, S Wang… - …, 2022 - Wiley Online Library
Small‐molecule inhibitors of MDM2 that block the MDM2‐p53 protein‐protein interaction
have been considered as potential therapeutic agents for the treatment of cancer. Here, we …
have been considered as potential therapeutic agents for the treatment of cancer. Here, we …
Reaction of Hetareno[e]pyrrole‐2,3‐diones with Thiols: An Approach to Two Distinct 5‐Thio‐Substituted Pyrrole‐2‐one Derivatives
DN Lukmanova, DI Pchelintseva, MV Dmitriev… - …, 2021 - Wiley Online Library
Abstract Recently, 3‐hydroxy‐1, 5‐dihydro‐2H‐pyrrol‐2‐ones have become an object of
close scrutiny in medicinal chemistry due to their diverse biological activity. In the present …
close scrutiny in medicinal chemistry due to their diverse biological activity. In the present …