The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …

Uncontrolled inflammation underpins a diverse range of diseases where effective therapy
remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory …

Simple Summary Cancers have regions of low oxygen concentration where hypoxia-related
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …

EGLN3 is critically important for growth of various cancers including lung cancer. However,
virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in …

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive
pathways is strongly implicated in fibrosis. We previously reported that altered collagen …

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting
physiological oxygen variations, and its irregularity leads to various human diseases …

The importance of oxygen for the survival of multicellular and aerobic organisms is well
established and documented. Over the years, increased knowledge of its use for …

Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3)
to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the …

Significance: Limited oxygen availability (hypoxia) commonly occurs in a range of
physiological and pathophysiological conditions, including embryonic development …