A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Nanoparticles in drug delivery: From history to therapeutic applications

O Afzal, ASA Altamimi, MS Nadeem, SI Alzarea… - Nanomaterials, 2022 - mdpi.com
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …

Progress of microfluidic hydrogel‐based scaffolds and organ‐on‐chips for the cartilage tissue engineering

H Tolabi, N Davari, M Khajehmohammadi… - Advanced …, 2023 - Wiley Online Library
Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

[HTML][HTML] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders

H Okano, S Morimoto - Cell Stem Cell, 2022 - cell.com
It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Recent advances in 3D printing of biomedical sensing devices

MA Ali, C Hu, EA Yttri, R Panat - Advanced functional materials, 2022 - Wiley Online Library
Additive manufacturing, also called 3D printing, is a rapidly evolving technique that allows
for the fabrication of functional materials with complex architectures, controlled …

Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank

Z Zhou, L Cong, X Cong - Frontiers in Oncology, 2021 - frontiersin.org
Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

Liver organ-on-chip models for toxicity studies and risk assessment

T Messelmani, L Morisseau, Y Sakai, C Legallais… - Lab on a Chip, 2022 - pubs.rsc.org
The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

Current state of knowledge on intelligent-response biological and other macromolecular hydrogels in biomedical engineering: A review

M Su, L Ruan, X Dong, S Tian, W Lang, M Wu… - International Journal of …, 2023 - Elsevier
Because intelligent hydrogels have good biocompatibility, a rapid response, and good
degradability as well as a stimulus response mode that is rich, hydrophilic, and similar to the …

[HTML][HTML] The gut–organ-axis concept: Advances the application of gut-on-chip technology

Y Guo, X Chen, P Gong, G Li, W Yao… - International Journal of …, 2023 - mdpi.com
The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest
immune organ, while numerous microorganisms coexist with the host. It is well known that …

Microfluidic organoids-on-a-chip: The future of human models

G Saorin, I Caligiuri, F Rizzolio - Seminars in cell & developmental biology, 2023 - Elsevier
Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …