Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …

Like other post-translational modifications (PTMs) of proteins, S-nitrosylation has been
considered a key regulatory mechanism of multiple cellular functions in many physiological …

Cone snails are predatory marine gastropods characterized by a sophisticated venom
apparatus responsible for the biosynthesis and delivery of complex mixtures of cysteine-rich …

The S-nitrosoglutathione reductase (GSNOR) is a key denitrosating enzyme that regulates
protein S-nitrosation, a process which has been found to be involved in the pathogenesis of …

Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have
inteins inserted into several important genes, including those corresponding to the iron …

Persistent pulmonary hypertension of the newborn (PPHN) is a hypoxic disorder of
pulmonary vascular relaxation, mediated in part by adenylyl cyclase (AC). Neonatal …

Morphine, a typical opiate, is widely used for controlling pain but can lead to various side
effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia. At …

The control of the excitability in magnocellular neurosecretory cells (MNCs) of the supraoptic
nucleus has been attributed mainly to synaptic inputs from circunventricular organs …

Nitric oxide (NO) is a signaling molecule which controls a variety of biological functions and
plays important roles in plant physiology. NO is involved in the majority of plant responses to …

Nitric oxide (NO) is a comprehensive regulator of vascular and airway tone. Endogenous NO
produced by nitric oxide synthases regulates multiple signaling cascades, including …