Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but …

Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes
leading to a change to the amino acid sequence of the encoded protein. Many of these …

Technological advancement has opened the door to systematic genetics in mammalian
cells. Genome‐scale loss‐of‐function screens can assay fitness defects induced by partial …

Although our knowledge of human diseases has increased dramatically, the molecular
basis, phenotypic traits, and therapeutic targets of most diseases still remain unclear. An …

Joint association analysis of multiple traits in a genome-wide association study (GWAS), ie.
a multivariate GWAS, offers several advantages over analyzing each trait in a separate …

Background Scientists have been trying to understand the molecular mechanisms of
diseases to design preventive and therapeutic strategies for a long time. For some diseases …

Highly networked signaling hubs are often associated with disease, but targeting them
pharmacologically has largely been unsuccessful in the clinic because of their functional …

With the rapid accumulation of our knowledge on diseases, disease-related genes and drug
targets, network-based analysis plays an increasingly important role in systems biology …

Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …

Background Understanding the relationship between diseases based on the underlying
biological mechanisms is one of the greatest challenges in modern biology and medicine …