Considerations of medical preparedness to assess and treat various populations during a radiation public health emergency

TA Winters, DR Cassatt… - Radiation …, 2023 - meridian.allenpress.com
During a radiological or nuclear public health emergency, given the heterogeneity of civilian
populations, it is incumbent on medical response planners to understand and prepare for a …

Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model

N Chakraborty, GP Holmes-Hampton, A Gautam… - Scientific Reports, 2023 - nature.com
Early diagnosis of lethal radiation is imperative since its intervention time windows are
considerably short. Hence, ideal diagnostic candidates of radiation should be easily …

Establishing pediatric mouse models of the hematopoietic acute radiation syndrome and the delayed effects of acute radiation exposure

AM Patterson, R Sellamuthu, PA Plett… - Radiation …, 2021 - meridian.allenpress.com
Medical countermeasures (MCMs) for hematopoietic acute radiation syndrome (H-ARS)
should be evaluated in well-characterized animal models, with consideration of at-risk …

Opportunities and challenges with animal models for acute radiation syndrome drug discovery

VK Singh, PT Santiago, TJ MacVittie - Expert Opinion on Drug …, 2018 - Taylor & Francis
Radiation exposures from accidents or other sources of radiation can result in different types
of radiation injuries, dictating the diagnostic and therapeutic measures. The clinical …

Neulasta regimen for the hematopoietic acute radiation syndrome: effects beyond neutrophil recovery

B Legesse, A Kaur, D Kenchegowda, B Hritzo… - International Journal of …, 2019 - Elsevier
Purpose Understanding the physiopathology underlying the acute radiation syndrome
(ARS) and the mechanism of action of drugs known to ameliorate ARS is expected to help …

Selective insulin-like growth factor resistance associated with heart hemorrhages and poor prognosis in a novel preclinical model of the hematopoietic acute radiation …

D Kenchegowda, B Legesse, B Hritzo… - Radiation …, 2018 - meridian.allenpress.com
Although bone marrow aplasia has been considered for the past decades as the major
contributor of radiation-induced blood disorders, cytopenias alone are insufficient to explain …

Impairment of IGF-1 signaling and antioxidant response are associated with radiation sensitivity and mortality

S Y. Aghdam, D Kenchegowda… - International Journal of …, 2021 - mdpi.com
Following exposure to high doses of ionizing radiation, diverse strains of vertebrate species
will manifest varying levels of radiation sensitivity. To understand the inter-strain cellular and …

CIRCULATING miRNA MARKERS FOR DETECTION OF RADIATION EXPOSURE

NM Chakraborty, SP Ghosh, A Gautam… - US Patent App. 18 …, 2024 - Google Patents
Early diagnosis of lethal radiation is imperative, since the intervention time windows for
lethally irradiated subjects are considerably short. Hence, ideal diagnostic candidates of …