Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

TV Peres, MRC Schettinger, P Chen… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Manganese: its role in disease and health

KM Erikson, M Aschner - Met. Ions Life Sci, 2019 - degruyter.com
Manganese is an essential dietary element that functions primarily as a coenzyme in several
biological processes. These processes include, but are not limited to, macronutrient …

The impact of manganese on neurotransmitter systems

ATG Soares, A de Castro Silva, AA Tinkov… - Journal of Trace …, 2020 - Elsevier
Abstract Background Manganese (Mn) is a metal ubiquitously present in nature and
essential for many living organisms. As a trace element, it is required in small amounts for …

Role for calcium signaling in manganese neurotoxicity

OM Ijomone, OM Aluko, COA Okoh… - Journal of Trace …, 2019 - Elsevier
Background Calcium is an essential macronutrient that is involved in many cellular
processes. Homeostatic control of intracellular levels of calcium ions [Ca 2+] is vital to …

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese

JA Roth - Neurotoxicology, 2014 - Elsevier
The studies presented in this review attempt to describe the operative properties of the
genes involved in generation of early and late onset of Parkinson's disease or Parkinson …

Manganese exposure leads to depressive-like behavior through disruption of the Gln–Glu–GABA metabolic cycle

Y Bi, N Huang, D Xu, S Wu, Q Meng, H Chen… - Journal of Hazardous …, 2024 - Elsevier
There is a correlation between long-term manganese (Mn) exposure and the Parkinson's-
like disease (PD), with depression as an early symptom of PD. However, the direct …

Butyrylcholinesterase—a potential plasma biomarker in manganese-induced neurobehavioral changes

A Anjum, S Biswas, M Rahman, A Rahman… - … Science and Pollution …, 2019 - Springer
Groundwater particularly drinking water contamination with metals has created an
environmental disaster in Bangladesh. Manganese (Mn), an essential trace element, plays a …

Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish

K Tuschl, RJ White, C Trivedi… - Disease Models & …, 2022 - journals.biologists.com
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited
manganese transporter defect caused by mutations in SLC39A14. To identify novel potential …

The relationship between selected bioelements and depressiveness associated with testosterone deficiency syndrome in aging men

I Rotter, A Wiatrak, A Rył, K Kotfis, Ż Ciosek… - Medicina, 2020 - mdpi.com
Background and Objectives: Abnormal concentrations of bioelements (magnesium,
manganese, chromium, copper, zinc) have been associated with physical and emotional …

[PDF][PDF] Epigenetics involvement in Parkinson's disease and manganese-induced neurotoxicity

Y Qiao, H Shao, JC Ng, C Peng - Journal of Clinical Epigenetics, 2015 - core.ac.uk
Parkinson's disease (PD) is a progressive neurological disorder of CNS and one of the most
common neurodegenerative diseases. The exact mechanisms underlying PD has been …