Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial tissue
inflammation and joint destruction associated with the activation of angiogenesis …

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci,
ligaments and subchondral bone, and synovial inflammation. Biomarkers are being …

Objective To investigate the role of matrix metalloproteinase 13 (MMP‐13; collagenase 3) in
osteoarthritis (OA). Methods OA was surgically induced in the knees of MMP‐13–knockout …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

The IL-6 family of cytokines comprises a large group of cytokines that all act via the formation
of a signaling complex that includes the glycoprotein 130 (gp130) receptor. Despite this …

Objectives To investigate the effect of leptin on cartilage destruction. Methods Collagen
release was assessed in bovine cartilage explant cultures, while collagenolytic and …

Introduction Acute trauma involving the anterior cruciate ligament is believed to be a major
risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In …