In the era of precision medicine, multivalent and multispecific therapeutics present a
promising approach for targeted disease intervention. These therapeutics are designed to …

Self‐assembling polyhedral protein biomaterials have gained attention as engineering
targets owing to their naturally evolved sophisticated functions, ranging from protecting …

Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …

Protective immunity following vaccination is sustained by long-lived antibody-secreting cells
and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 …

Introduction Assessing the response to vaccinations is one of the diagnostic criteria for
Common Variable Immune Deficiencies (CVIDs). Vaccination against SARS-CoV-2 offered …

The aim of this study was to analyze the profiles of IgG subclasses in COVID-19
convalescent Puerto Rican subjects and compare these profiles with those of non-infected …

Sequential dengue virus (DENV) infections often generate neutralizing antibodies against
all four DENV serotypes and sometimes, Zika virus. Characterizing cross-flavivirus broadly …

New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-
CoV-2 temporally across the pandemic starting with the first emergence of the virus in the …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes
debilitating swelling and destruction of the joints. People with RA are treated with drugs that …

Polymeric IgMs are secreted from plasma cells abundantly despite their structural complexity
and intricate multimerization steps. To gain insights into IgM's assembly mechanics that …