Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL) 23/IL17
axis plays an important role in the development of psoriasis. The effectiveness of biologic …

Rho kinases (ROCKs) belong to the serine–threonine family, the inhibition of which affects
the function of many downstream substrates. As such, ROCK inhibitors have potential …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

One of the main research areas in biology from the mid‐1980s through the 1990s was the
elucidation of signaling pathways governing cell responses. These studies brought, among …

Rho-associated kinase 2 (ROCK2) regulates the secretion of proinflammatory cytokines and
the development of autoimmunity in mice. Data from a phase 1 clinical trial demonstrate that …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

The intestinal epithelial apical junctional complex, which includes tight and adherens
junctions, contributes to the intestinal barrier function via their role in regulating paracellular …