Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the
cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane …

▪ Abstract The actin cytoskeleton plays a major role in morphological development of
neurons and in structural changes of adult neurons. This article reviews the myriad functions …

▪ Abstract Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of
phosphatidylinositol (PI)] have a pivotal role as precursors to important second messengers …

▪ Abstract Eukaryotic cells use actin polymerization to change shape, move, and internalize
extracellular materials by phagocytosis and endocytosis, and to form contractile structures …

Although many of the regulators of actin assembly are known, we do not understand how
these components act together to organize cell shape and movement. To address this …

The innate immune response is critical for animal homeostasis and is conserved from
invertebrates to vertebrates. This response depends on specialized cells that recognize …

The organization of bristles on the Drosophila notum has long served as a popular model of
robust tissue patterning. During this process, membrane-tethered Delta activates …