Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Brain-derived neurotrophic factor dysregulation as an essential pathological feature in Huntington's disease: mechanisms and potential therapeutics

A Speidell, N Bin Abid, H Yano - Biomedicines, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

[PDF][PDF] 运动干预脑衰老: 新进展与再认识

李雪, 孙君志, 金毓, 王璐 - 科技导报, 2022 - kjdb.org
摘要随着人口老龄化的日益严峻, 衰老及其带来的多种慢性疾病已成为亟待解决的社会问题.
综述了脑衰老发病的复杂生物学机制, 包括胶质细胞激活及炎症反应, 氧化应激损伤 …

Synaptic Mechanisms of Delay Eyeblink Classical Conditioning: AMPAR Trafficking and Gene Regulation in an In Vitro Model

J Keifer - Molecular Neurobiology, 2023 - Springer
An in vitro model of delay eyeblink classical conditioning was developed to investigate
synaptic plasticity mechanisms underlying acquisition of associative learning. This was …

Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism

S Yunusa, Z Hassan, CP Müller - Pharmacological Reports, 2023 - Springer
Background Mitragynine (MIT), the primary indole alkaloid of kratom (Mitragyna speciosa),
has been associated with addictive and cognitive decline potentials. In acute studies, MIT …

Prefrontal Cortical Projection Neurons: Involvement in Shaping Different Types of Behaviors, BDNF Expression and Transport

US Drozd, YA Frik, AV Smagin… - Journal of Evolutionary …, 2024 - Springer
The prefrontal cortex (PFC) plays a key role in cognitive plasticity and is involved in various
processes of higher nervous activity. At the same time, studying the processes underlying …

Exercise intervention of brain aging: New progress and revisit

X LI, J SUN, Y JIN, L WANG - Science & Technology Review, 2022 - kjdb.org
The aging and the chronic diseases caused by the aging are an urgent social problem in
facing the ever increased aging population. This paper reviews the complex biological …

[PDF][PDF] БИОХИМИЧЕСКИЕ ИЗМЕНЕНИЯ В КЛЕТКАХ ГИППОКАМПА КРЫС СО ФТОР-ИНДУЦИРОВАННЫМ КОГНИТИВНЫМ ДЕФИЦИТОМ

ОВ Надей - iephb.ru
Фтор (F)–элемент из группы галогенов с атомным номером 9 и молекулярной массой
18.99. В составе неорганических и органических соединений он чрезвычайно широко …