Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

Because of its rapid progression and frequently poor prognosis, stroke is the third major
cause of death in Europe and the first one in China. Many independent studies …

Xanthine oxidase (XO), a form of xanthine oxidoreductase, is widely distributed in various
human tissues. As a major source for the generation of superoxide radicals, XO is involved …

In recent years, the disease burden of hyperuricemia has been increasing, especially in high-
income countries and the economically developing world with a Western lifestyle. Abnormal …

Vascular cognitive impairment (VCI) and depression frequently coexist in geriatric
populations and reciprocally increase disease risks. We assert that a shared pre-disease …

Heart failure (HF) is one of the leading causes of death worldwide. HF results not only in
cardiovascular dysfunction, but also numerous pathologies in the oral cavity and salivary …

Metabolomics is a powerful data-driven tool for in-depth biological phenotyping that could
help identify the specific metabolic profile of cryptogenic strokes, for which no precise cause …

Background Enzymes with critical effects on life systems are regulated by expression and
activation to modulate life processes. However, further insights into enzyme functions and …

Background: Cerebral stroke is a leading cause of death and disability worldwide.
Ligusticum Chuanxiong Hort.(LCH), a well-known Chinese herb, is widely used for the …

Due to the fact that cardiovascular diseases (CVDs) have become the most serious problem
in public health, there is a need for new and efficient methods for screening and early …