The systematic separation strategy has long and widely been applied in the research and
development of herbal medicines. However, the pharmacological effects of many bioactive …

Biological systems are composed of numerous components of which proteins are of
particularly high functional significance. Network models are useful abstractions for studying …

Oral administration is the most commonly used route for drug treatment. Intestinal
cytochrome P450 (CYP)-mediated metabolism can eliminate a large proportion of some …

The purpose of the present study was to examine simultaneously the absolute protein
amounts of 152 membrane and membrane‐associated proteins, including 30 metabolizing …

Intestinal metabolism can limit oral bioavailability of drugs and increase the risk of drug
interactions. It is therefore important to be able to predict and quantify it in drug discovery …

Tramadol is widely used to manage mild to moderately painful conditions in dogs. However,
this use is controversial, since clinical efficacy studies in dogs showed conflicting results …

Since their inception in pharmaceutical applications, physiologically-based kinetic (PBK)
models are increasingly being used across a range of sectors, such as safety assessment of …

This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs versus
humans. Identifying these interspecies differences can facilitate canine-human PK …

Cytochromes P450 (P450s or CYPs) are important drug-metabolizing enzymes. Because
dogs are frequently used in drug metabolism studies, knowledge of dog CYP2C enzymes is …

Over the last 5 years the quantification of transporter-protein absolute abundances has
dramatically increased in parallel to the expanded use of in vitro–in vivo extrapolation …