Radioprotection of normal tissue cells
P Maier, F Wenz, C Herskind - Strahlentherapie und onkologie, 2014 - search.proquest.com
Improvements of radiotherapy in combination with surgery and systemic therapy have
resulted in increased survival rates of tumor patients. However, radiation-induced normal …
resulted in increased survival rates of tumor patients. However, radiation-induced normal …
Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells
The mutagenic and carcinogenic potency of betel-nut components is well established. This
study was undertaken to determine the genotoxic potency of an aqueous extract of raw betel …
study was undertaken to determine the genotoxic potency of an aqueous extract of raw betel …
Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes: a comet assay study
L BENÍTEZ‐BRIBIESCA… - Annals of the New …, 1999 - Wiley Online Library
Most anticancer treatments such as chemo‐and radiotherapy induce DNA damage and
apoptosis in normal cells. The aim of this study was to assess the induction of single and …
apoptosis in normal cells. The aim of this study was to assess the induction of single and …
Effect of thiol compounds on bleomycin-induced DNA and chromosome damage in human cells
A Mira, EM Gimenez, AD Bolzan… - … of Environmental & …, 2013 - Taylor & Francis
Non-protein thiols are considered radioprotectors, preventing DNA damage by ionizing
radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may …
radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may …
Antiproliferative and cytotoxic effect of a novel organotin compound on mammalian cells both in vitro and in vivo
C Syng-ai, TSB Baul, A Chatterjee - Mutation Research/Genetic Toxicology …, 2002 - Elsevier
Organotin compounds are organometallic compounds showing various toxicological
properties. Several organotin compounds also showed an antineoplastic effect. However …
properties. Several organotin compounds also showed an antineoplastic effect. However …
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
CE Olsen, S Sellevold, T Theodossiou, S Patzke… - Photodiagnosis and …, 2017 - Elsevier
The low curative response to current treatment regimens for most soft tissue sarcomas
indicates a strong need for alternative treatment strategies and predictive markers for …
indicates a strong need for alternative treatment strategies and predictive markers for …
Bleomycin genotoxicity alteration by glutathione and cytochrome P-450 cellular content in respiratory proficient and deficient strains of Saccharomyces cerevisiae
P Poli, A Buschini, A Candi, C Rossi - Mutagenesis, 1999 - academic.oup.com
The genotoxic effects of the antiblastic drug bleomycin were studied in the D7 strain of
Saccharomyces cerevisiae and on its derivative mitochondrial mutant ρ° at different cellular …
Saccharomyces cerevisiae and on its derivative mitochondrial mutant ρ° at different cellular …
Inhibition of cell proliferation and antitumor activity of a novel organotin compound
C Syng-ai, TSB Baul… - Journal of environmental …, 2001 - dl.begellhouse.com
Organotin compounds showed more antineoplastic effect against P388 leukemia in mice
than any other class of compounds. However, they have not received as much attention as …
than any other class of compounds. However, they have not received as much attention as …
Interaction of radiation-and bleomycin-induced lesions and influence of glutathione level on the interaction
Radiation-induced exchange aberrations are thought to arise as a consequence of
misrejoining of free ends of DNA double strand breaks (dsbs). In quiescent mammalian cells …
misrejoining of free ends of DNA double strand breaks (dsbs). In quiescent mammalian cells …
Structure–activity analysis of the potentiation by aminothiols of the chromosome‐damaging effect of bleomycin in G0 human lymphocytes
GR Hoffmann, J Buccola, MS Merz… - Environmental and …, 2001 - Wiley Online Library
Abstract The radioprotective aminothiols 2‐[(aminopropyl) amino] ethanethiol (WR‐1065)
and cysteamine (CSM) potentiate the induction of chromosomal damage by the …
and cysteamine (CSM) potentiate the induction of chromosomal damage by the …