Background Medication-induced salivary gland dysfunction (MISGD), xerostomia (sensation
of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of …

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

Depression is perhaps the most frequent cause of emotional suffering in later life and
significantly decreases quality of life in older adults. In recent years, the literature on late-life …

Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis …

Background: Second-generation antidepressants dominate the management of major
depressive disorder (MDD), but evidence on the comparative benefits and harms of these …

This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …

Background: The neurochemical and biological effects of antidepressant medications have
become better defined over the last decade. When the antidepressant bupropion was …

Objective: To identify drugs associated with the complaint of dry mouth. Materials and
Methods: MEDLINE was searched for papers 1980–2002 using keywords, oral, mouth …

Key Clinical Points Depression in the Elderly Late-life depression (occurring in persons 60
years of age or older) is common and is often associated with coexisting medical illness …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …