Infectious diseases remain a global threat contributing to excess morbidity and death
annually, with the persistent potential for destabilizing pandemics. Improved understanding …

CRISPR/Cas9 technology has revolutionized biology. This prokaryotic defense system
against foreign DNA has been repurposed for genome editing in a broad range of cell …

In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …

In vertebrate cells, mitochondrial Ca 2+ uptake by the mitochondrial calcium uniporter
(MCU) leads to Ca 2+-mediated stimulation of an intramitochondrial pyruvate …

Trypanosoma cruzi, the agent of Chagas disease, must adapt to a diversity of environmental
conditions that it faces during its life cycle. The adaptation to these changes is mediated by …

Protein phosphorylation is involved in several key biological roles in the complex life cycle of
Trypanosoma cruzi, the etiological agent of Chagas disease, and protein kinases are …

Kinetoplastids are unicellular eukaryotic flagellated parasites found in a wide range of hosts
within the animal and plant kingdoms. They are known to be responsible in humans for …

The flagellated kinetoplastid protozoan and causative agent of human Chagas disease,
Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its …

There is an urgent need to develop new treatments for Chagas' disease. To identify drug
targets, it is important to understand the basic biology of Trypanosoma cruzi, in particular …

Eating is fundamental and from this basic principle, living organisms have evolved
innumerable strategies to capture energy and nutrients from their environment. As part of the …