Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …

The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical
counterpart, the Wnt/b-catenin pathway. The non-canonical Wnt signaling pathways are …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …

Background: The precise details of pancreatic ductal adenocarcinoma (PDAC)
pathogenesis are still insufficiently known, requiring the use of higthroughput methods …

Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much
progress concerning its molecular characterization. PDA tumours harbour four signature …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Wnt ligand expression and activation of the Wnt/β-catenin pathway have been associated
with pancreatic ductal adenocarcinoma, but whether Wnt activity is required for the …

Pancreatic cancer is one of the most lethal malignancies. Significant progresses have been
made in understanding of pancreatic cancer pathogenesis, including appreciation of …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent
desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease …

The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature
collagen 11A1, an extracellular minor fibrillar collagen. Under regular conditions, this gene …