Effects of lipopolysaccharide-binding protein (LBP) single nucleotide polymorphism (SNP) in infections, inflammatory diseases, metabolic disorders and cancers

L Meng, Z Song, A Liu, U Dahmen, X Yang… - Frontiers in …, 2021 - frontiersin.org
Inflammation, which is induced by the immune response, is recognized as the driving factor
in many diseases, including infections and inflammatory diseases, metabolic disorders and …

[HTML][HTML] Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

W Yang, X Bai, X Luan, J Min, X Tian, H Li, H Li, W Sun… - Cell reports, 2022 - cell.com
The inflammatory response is tightly regulated, but its regulatory principles are still
incompletely understood. Cyclophilin A (CypA) has long been considered as a pro …

Diffusive mediator feedbacks control the health-to-disease transition of skin inflammation

M Sudo, K Fujimoto - PLOS Computational Biology, 2024 - journals.plos.org
The spatiotemporal dynamics of inflammation provide vital insights into the understanding of
skin inflammation. Skin inflammation primarily depends on the regulatory feedback between …

[HTML][HTML] Is pulmonary inflammation a valid predictor of particle induced lung pathology? The case of amorphous and crystalline silicas

CA Poland, R Duffin, K Weber, W Dekant, PJA Borm - Toxicology Letters, 2023 - Elsevier
Although inflammation is a normal and beneficial response, it is also a key event in the
pathology of many chronic diseases, including pulmonary and systemic particle-induced …

Spatial considerations in the resolution of inflammation: elucidating leukocyte interactions via an experimentally-calibrated agent-based model

A Bayani, JL Dunster, JJ Crofts… - PLOS Computational …, 2020 - journals.plos.org
Many common medical conditions (such as cancer, arthritis, chronic obstructive pulmonary
disease (COPD), and others) are associated with inflammation, and even more so when …

[HTML][HTML] Modelling the continuum of macrophage phenotypes and their role in inflammation

S Almansour, JL Dunster, JJ Crofts, MR Nelson - Mathematical Biosciences, 2024 - Elsevier
Macrophages are a type of white blood cell that play a significant role in determining the
inflammatory response associated with a wide range of medical conditions. They are highly …

Exploring the constituent mechanisms of hepatitis: a dynamical systems approach

JL Dunster, JM Gibbins… - Mathematical Medicine and …, 2023 - academic.oup.com
Hepatitis is the term used to describe inflammation in the liver. It is associated with a high
rate of mortality, but the underlying disease mechanisms are not completely understood and …

[HTML][HTML] Platelet-driven routes to chaos in a model of hepatitis

MR Nelson, JM Gibbins, JL Dunster - Chaos, Solitons & Fractals, 2023 - Elsevier
Hepatitis is a general term used to describe inflammation in the liver, the regulation of which
involves a complex array of interactions between liver cells, inflammatory mediators and …

A systematic evaluation of the influence of macrophage phenotype descriptions on inflammatory dynamics

S Almansour, JL Dunster, JJ Crofts… - … Medicine and Biology …, 2024 - academic.oup.com
Macrophages play a wide range of roles in resolving the inflammatory damage that
underlies many medical conditions, and have the ability to adopt different phenotypes in …

[PDF][PDF] Polyunsaturated fatty acids and lipid mediators controlling chronic inflammation in asthma

OY Kytikova, YK Denisenko, TP Novgorodtseva… - Russian Open Medical …, 2023 - romj.org
Asthma is a common chronic heterogeneous inflammatory respiratory disease with complex
pathogenesis. Chronic lung inflammation can be the result of a defect in the resolution of the …