[PDF][PDF] The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Parkinson's disease: etiology, neuropathology, and pathogenesis
A Kouli, KM Torsney, WL Kuan - Exon Publications, 2018 - exonpublications.com
Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …
nonmotor manifestations arise, the typical clinical features involve a movement disorder …
[HTML][HTML] Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
Microglia maintain brain homeostasis by removing neuron-derived components such as
myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is …
myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is …
[HTML][HTML] Neuropathology of Alzheimer's disease
JA Trejo-Lopez, AT Yachnis, S Prokop - Neurotherapeutics, 2023 - Elsevier
The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
[HTML][HTML] Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …
was identified as an important player in a complex neurodegenerative disease that affects> …
Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease
INTRODUCTION Parkinson's disease (PD) is the second most common neurodegenerative
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …
[HTML][HTML] Neuropharmacological effects of quercetin: a literature-based review
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its
beneficial properties in many pathologies. Its neuroprotective effects have been …
beneficial properties in many pathologies. Its neuroprotective effects have been …
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …