Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for
polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role …

Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …

The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …