Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

African lungfish genome sheds light on the vertebrate water-to-land transition

K Wang, J Wang, C Zhu, L Yang, Y Ren, J Ruan, G Fan… - Cell, 2021 - cell.com
Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked
with the water-to-land transition. However, their huge genome sizes have hindered …

[HTML][HTML] Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation

YY Zuo, RAW Veldhuizen, AW Neumann… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10%
proteins. It plays an important role in maintaining normal respiratory mechanics by reducing …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

Pulmonary alveolar proteinosis

BC Trapnell, K Nakata, F Bonella, I Campo… - Nature Reviews …, 2019 - nature.com
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of
alveolar surfactant and dysfunction of alveolar macrophages. PAP results in progressive …

Interactions of particulate matter and pulmonary surfactant: Implications for human health

F Wang, J Liu, H Zeng - Advances in colloid and interface science, 2020 - Elsevier
Particulate matter (PM), which is the primary contributor to air pollution, has become a
pervasive global health threat. When PM enters into a respiratory tract, the first body tissues …

Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Autoimmune pulmonary alveolar proteinosis

C McCarthy, BC Carey, BC Trapnell - American journal of …, 2022 - atsjournals.org
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare disease characterized by
myeloid cell dysfunction, abnormal pulmonary surfactant accumulation, and innate immune …

Cholesterol rules: direct observation of the coexistence of two fluid phases in native pulmonary surfactant membranes at physiological temperatures

JB de la Serna, J Perez-Gil, AC Simonsen… - Journal of Biological …, 2004 - ASBMB
Pulmonary surfactant, the lipid-protein material that stabilizes the respiratory surface of the
lungs, contains approximately equimolar amounts of saturated and unsaturated …